CONSENT OF INDEPENDENT REGISTERED PUBLIC
We consent to the reference to our firm under the caption "Experts"
in this Amendment No. 1 to the Registration Statement (Form
S-3/A) and related Prospectus of Proteon Therapeutics, Inc.
for the registration of Common Stock and to the incorporation by reference therein of our report dated March 16, 2017, with respect
to the consolidated financial statements of Proteon Therapeutics, Inc. included in its Annual Report (Form 10-K) for the year ended
December 31, 2016, filed with the Securities and Exchange Commission.
Ernst & Young LLP
August 14, 2017