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PROTEON THERAPEUTICS INC filed this Form S-1 on 09/16/2014
Entire Document

Exhibit 10.13


[Department of Health & Human Services Letterhead]


National Institutes of Health

Bethesda, Maryland 20892


October 1st, 2010




F. Nicholas Franano, M.D.

1010 W. 69th Terrace

Kansas City, MO 64113


Invention Title: Local, transcatheter delivery of proteases to reopen obstructed biological conduits

Inventor(s):  F. Nicholas Franano

NIH Grant #: HL007712

NIH EIR #: 9999207-99-0001

Patents: 7,361,335; 7,632,494; 7,063,838; 7,153,505.

Patent publications: 12/229,372; 11/454,554, 12/229,428.

Reference: Third Party Waiver Request — F. Nicholas Franano to Proteon Therapeutics, Inc.


Dear Dr. Franano,


In reference to your request for approval to make an assignment of rights from F. Nicholas Franano to Proteon Therapeutics, Inc., the NIH has approved your request. Please note however, that the provisions of 37 CFR 401 continue to apply to any assignee(s) herein and its/their successor(s) once you have executed the transfer. In addition, terms applicable to the original funding agreement, including, but not limited to, rights in data and sharing of unique research resources, also flow down to the assignee(s), if applicable to the original recipient. In this case, the Invention ownership has already been assigned from Johns Hopkins University to you personally, and this letter gives approval for the title of the intellectual property to go now to Proteon Therapeutics, Inc. These terms need to be incorporated, at least by reference, in the assignment document.


It is your responsibility to notify the assignee(s)/recipient(s) of this transfer of the decision of our office for this Third Party Waiver to permit assignment to Proteon Therapeutics, Inc. Also, both parties involved are required to sign and send a copy of this letter back to our office at the address or fax number listed below.


Annual Utilization Reports detailing utilization-related activities related to the Subject Invention continue to be required. In addition the filing and maintenance of any Patents and/or Patent Applications claiming the Subject Invention is required, unless waived with proper notice and lead time so that the Government may Elect Title if it chooses to do so. These terms also need to be incorporated, at least by reference, in the assignment document.


Finally, the authorized representative of the Assignee, in this case Proteon Therapeutics, Inc., should go to the iEdison Invention and Patent Reporting web site, located at, and register within 90 days from the date of this notification. This iEdison web site permits the Assignee to make the required reports on the assigned inventions. Once the Assignee registers at the iEdison web site, our office needs to be contacted at (301) 435-1986 to transfer the technology appropriately to the new iEdison account of the Assignee.