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affect investors' perception of our corporate governance or delay, prevent or cause a change in control of our company, any of which could adversely affect the market price of our common
Sales of a substantial number of shares of our common stock by our existing stockholders in the public market may cause our stock price to decline.
Sales of our common stock in the public market after this offering, or the perception that these sales may occur, could cause the
market price of our common stock to decline. Upon the closing of this offering, we will have 14,045,374 shares of common stock outstanding, assuming no exercise of the underwriters' option to purchase
additional shares. Of these, only the shares of our common stock sold in this offering, plus any shares sold upon exercise of the underwriters' option to purchase additional shares, will be freely
transferable without restriction or additional registration under the Securities Act of 1933, as amended, or the Securities Act. The remaining shares outstanding after this offering will be available
for sale, upon the expiration of the 180-day lock-up period beginning from the date of this prospectus, if applicable, subject to volume and other restrictions as applicable under Rule 144
under the Securities Act. Any or all of these shares may be released prior to expiration of the lock-up period at the discretion of the lead underwriters for this offering. After the lock-up
agreements expire, up to an additional 9,345,374 shares of common stock will be eligible for sale in the public market, of which 8,027,984 shares are held by directors, executive officers and other
affiliates and will be subject to volume limitations under Rule 144 under the Securities Act, assuming an initial public offering price of $13.00 per share (the midpoint of the price range set
forth on the cover page of this prospectus). In addition, 1,977,552 shares of common stock that are either subject to outstanding options or reserved for future issuance under our employee benefit
plans will become eligible for sale in the public market to the extent permitted by the provisions of various vesting schedules, the lock-up agreements and Rule 144 and Rule 701 under
the Securities Act. To the extent these shares are sold, or if it is perceived that they will be sold, into the market, the market price of our common stock could decline. For a further description of
the dilution that you will experience immediately after this offering, see the section entitled "Share Eligible for Future Sale."
Future sales and issuances of our common stock or rights to purchase common stock, including pursuant to our equity incentive plans, could result in additional dilution of
the percentage ownership of our stockholders and could cause our stock price to fall.
We expect that significant additional capital will be needed in the future to continue our planned operations, including conducting
clinical trials, commercialization efforts, expanded research and development activities and costs associated with operating a public company. To raise capital, we may sell common stock, convertible
securities or other equity securities in one or more transactions at prices and in a manner we determine from time to time. If we sell common stock, convertible securities or other equity securities
in more than one transaction, investors may be materially diluted by subsequent sales. Such sales may also result in material dilution to our existing stockholders, and new investors could gain
rights, preferences and privileges senior to the holders of our common stock, including shares of common stock sold in this offering.
You will experience immediate and substantial dilution in the net tangible book value of the shares you purchase in this offering.
If you purchase shares of our common stock in this offering, you will experience immediate and substantial dilution, as the initial
public offering price of our common stock will be substantially greater than the net tangible book value per share of our common stock. Based on an initial offering price of $13.00 per share, which is
the midpoint of the range on the cover page of this prospectus, if you purchase our common stock in this offering, you will suffer immediate and substantial dilution of approximately $7.63 per share.
Further, investors purchasing common stock in this offering will contribute approximately 37% of the total amount invested by stockholders since our inception, but will own only approximately 33% of
the shares of common stock outstanding after giving effect to this offering. If the underwriters